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Identification of a unique loss-of-function mutation in IGF1R and a crosstalk between IGF1R and Wnt/beta-catenin signaling pathways
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In addition, LipRSV treatment was associated with reduced BDNF and NGF levels, further indicating that redox modulation was not paralleled by neurotrophin restoration.Together, these results suggest limited therapeutic benefit of the formulation under the experimental conditions tested and highlight the complexity of linking redox modulation to functional behavioral outcomes in ASD models
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